There are only two cubes you have to worry about that will work on 99% of the units in the game: Resilience and Bastion.

Resilience provides reload speed, which works on ANY unit in the game. More uptime shooting = more damage.
Bastion is basically ammo “refund”, which works on most units as long as they don’t have a last bullet mechanic.
I would give priority to these two cubes for new players to at least level 7.
After that, you can take either of them to level 14. No need to go to max level (15) since you still get batteries on Solo Raid regardless.
Thankfully, we have a few cubes nowadays that are pretty good for endgame, mostly Solo and Union Raids.
New players should NOT worry about these until you have both Bastion and Resilience at level 14.

Pierce fills the niche of pierce characters like
Red Hood
Red Hood
,
Snow White
Snow White
and a lot more units in the current meta that can take advantage of this.
Rupture fills the niche of true damage characters like
Chisato Nishikigi
Chisato Nishikigi
or
Ein
Ein
.
Not as many units can take advantage of this cube, but it’s still worth considering to level up long term.
Lastly, Destruction can be used on ANY character as long as the boss you are facing has parts, since it increases the damage done to parts.
The last cube I can recommend for PVE content is Quantum, since it increases burst generation for the wearer.

This works pretty well on pure support units that deal no damage and have “bad” burst generation weapon types like
Liter
Liter
or
Helm: Aquamarine
Helm: Aquamarine
.
I would only work on Quantum cube IF every other cube mentioned previously it’s at least level 7.
